Comentario (11)

  • Djampatuan| 28 febrero, 2016

    have their problems, too. Sometimes they don’t work beacsue the cells simply fail to divide in culture. And the results cannot tell a researcher how anticancer drugs will act in the body. What’s more, new results from Bert Vogelstein’s group at Johns Hopkins University School of Medicine add another question mark about the assay’s predictive ability. Todd Waldman, a postdoc in the Vogelstein laboratory, found that xenografts and clonogenic assays deliver very different messages about how cancer cells lacking a particular gene, p21, respond to DNA-crippling agents. Radiation, like many of the drugs used to treat cancer, works by damaging the cells’ DNA. This either brings cell replication to a halt or triggers a process known as apoptosis in which the cells essentially commit suicide. Waldman wanted to see how p21, one of the genes involved in sensing the DNA damage and halting cell replication, influences that response to radiation. In the mouse xenograft assay, Waldman and his colleagues found that the radiation cured 40% of the tumors composed of cells lacking p21, while tumors made of cells carrying the gene were never cured. But this difference was not apparent in the clonogenic assay, where the radiation appeared to thwart the growth of both dispersed tumor cell types. “We showed this gross difference in sensitivity in real tumors in mice and in the clonogenic assay,” Waldman says. He suggests that the different responses in the two systems have to do with the fact that a subset of p21 mutants die in response to radiation, while cells with the normal gene merely arrest cell division. Either way, the dispersed tumor cells in the clonogenic assay will fail to grow. However, in the xenograft tumors, which consist of many cells in a solid mass, the arrested, but nonetheless living, p21+ tumor cells may release substances that encourage the growth of any nearby tumor cells that escaped the effects of the radiation. But tumor cells lacking the p21 gene die, and beacsue dead cells cannot “feed” neighboring tumor cells, the entire tumor may shrink.

  •| 28 abril, 2016

    I got upset when I saw some people I know handing out their very opinionated guides on how to vote. Some people are very influential and others will follow suit to gain favor. I think that public figures, internet celebrities, celebrities or super outspoken people that have a conscience, should be careful how they assert their “voting guides” and instead encourage their “followers” to do their own research and decide for themselves. Providing links to do the research is fine in my opinion as long as it includes both sides of the opinions.

  •| 28 abril, 2016

    Realmente, não dá pra fazer diferente: Parabéns coloradagi! Agora, nada de salto alto. Mostrem pros mexicanos quem é que manda aqui nesta porra!

  •| 4 junio, 2016

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  • quote auto insurance| 5 junio, 2016

    When I initially commented I seem to have clicked on the -Notify me when new commentsare added- checkbox and from now on each time a comment is added I receive four emailswith the same comment. There has to be a way you are able to remove me from that service?Thanks!

  •| 8 julio, 2016

    I agree with Ijr, aug.3, 2012. I’m looking this up to see if my husband & I can afford to rent enough beach homes to house EVERYONE coming — and, to see what else we need to cover. My son will have a hometown wedding, if we can’t.q

  •| 15 julio, 2016

    TomsyParents should be charged for leaving their kids with priests, what else is going to happen?Same could be said for leaving your children with a sitter, a day care or with a teacher, although yeah, priests do have a habit of diddling kids.VN:F [1.9.21_1169](from 0 votes)

  •| 20 julio, 2016

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  •| 20 julio, 2016

    Oui, vous pouvez faire de la purée. mélangez-la simplement avec un peu de jus pour jusqu’à la consistance voulue et passez le tout au mélangeur pour une texture lisse. N’oubliez pas que toutes les vitamines et autres propriétés des aliments se retrouveront dans le jus même donc pour un maximum de bienfaits, nous vous recommandons d’utiliser le plus de jus possible.

  • pilgrims insurance| 24 octubre, 2016

    i ate at congee village when i was in new york. 🙂 tastes like something from home. kekeooh food prices hasn't gone up? but the problem in the states is that some cities don't have access to fresh food! 🙁

  • kfz-haftpflichtversicherung vergleich anonym| 5 febrero, 2017

    bien tu vois Alain, il a attendu au lendemain ce qui est peu adroit et oui j’aurais préféré quil me dise quil me trouvait belle hier mais n’a pas osé me le dire que de me dire j’ai oublié de te dire que ta chemise était belle, un beau morceau de vêtement.

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